1. Feeling down, depressed, or hopeless for more than two weeks

2. Changes in appetite or sleep patterns (eating too much/too little, sleeping too much/too little)

3. Excessive worry or anxiety

4. Withdrawal from social activities or hobbies

5. Increased anger, irritability, or aggression

6. Difficulty concentrating, remembering things, or making decisions

7. Fatigue or loss of energy

8. Thoughts of death or suicide

9. Substance abuse (alcohol, drugs)

10. Physical aches and pains that don't respond to treatment