1. Deebo's dual threat Samuel excelled as both a receiver and rusher, creating matchup nightmares for defenses.

2. Aiyuk's time to shine? Brandon Aiyuk may get a bigger role after Samuel leaves, but can he repeat his production?

3. Pearsall's emergence Rookie WR Ricky Pearsall could be fast-tracked for playing time to fill the receiving void.

4. Focus on McCaffrey With Samuel gone, Christian McCaffrey may see more targets in the passing game.

5. Shanahan's plan is favorable Coach Kyle Shanahan is known for his creative schemes. How will he adjust without Samuel?

6. Offensive line a priority? The 49ers could use the freed-up cap space to strengthen their offensive line.

7. Impact on the running game Samuel's absence could impact the effectiveness of the 49ers' signature running game.

8. Short-term pain, long-term gain? Trading Samuel could save cap space but hurt the offense in 2024.

9. 9. Brock Purdy Question How will Purdy handle pressure without a top receiving weapon like Samuel?

10. A New Offensive Identity? The 49ers' offense could look very different without the unique skillset of Deebo Samuel.